What we’ve published…

Featured Publications

Featured
Manon's Paper is Published!
Manon's Paper is Published!

Independently engaging protein tethers of different length enhance synaptic vesicle trafficking to the plasma membrane

Click here to read more!

Using computational modelling, we show that proteins and protein complexes of different lengths, such as synaptotagmin-1, Munc13, and the SNARE complex, as well as their abundance at the active zone can enhance synaptic vesicle trafficking to the plasma membrane

Synaptotagmin 7 docks synaptic vesicles to support facilitation and Doc2α-triggered asynchronous release
Synaptotagmin 7 docks synaptic vesicles to support facilitation and Doc2α-triggered asynchronous release

eLife, March 2024

Zhenyong Wu,Grant F Kusick, Manon MM Berns, Sumana Raychaudhuri, Kie Itoh, Alexander M Walter, Edwin R Chapman, Shigeki Watanabe

Unc13A dynamically stabilizes vesicle priming at synaptic release sites for short-term facilitation and homeostatic potentiation
Unc13A dynamically stabilizes vesicle priming at synaptic release sites for short-term facilitation and homeostatic potentiation

Cell reports, June 2023
Meida Jusyte, Natalie Blaum, Mathias A. Bohme, Manon M.M. Berns, Alix E. Bonard, Abel B. Vamosi, Kavya V. Pushpalatha, Janus R.L. Kobbersmed, and Alexander M. Walter

Spontaneous neurotransmission at evocable synapses predicts their responsiveness to action potentials
Spontaneous neurotransmission at evocable synapses predicts their responsiveness to action potentials

Frontiers in Cellular Neuroscience, March 2023

Andreas T. Grasskamp, Meida Jusyte, Anthony W. McCarthy, Torsten W. B. Götz, Susanne Ditlevsen and Alexander M. Walter

Allosteric stabilization of calcium and phosphoinositide dual binding engages several synaptotagmins in fast exocytosis
Allosteric stabilization of calcium and phosphoinositide dual binding engages several synaptotagmins in fast exocytosis

Elife, aug. 2022

Janus RL Kobbersmed, Manon MM Berns, Susanne Ditlevsen, Jakob Balslev Sørensen, Alexander M Walter

Glial Synaptobrevin mediates peripheral nerve insulation, neural metabolic supply, and is required for motor function
Glial Synaptobrevin mediates peripheral nerve insulation, neural metabolic supply, and is required for motor function

Glia, sep 2021


Mathias A Böhme , Anthony W McCarthy, Natalie Blaum , Monika Berezeckaja , Kristina Ponimaskine , David Schwefel, Alexander M Walter

Rapid regulation of vesicle priming explains synaptic facilitation despite heterogeneous vesicle:Ca2+ channel distances (Copy)
Rapid regulation of vesicle priming explains synaptic facilitation despite heterogeneous vesicle:Ca2+ channel distances (Copy)

eLife, Feb 2020

Janus R. L. Kobbersmed, Andreas T. Grasskamp, Meida Jusyte, Mathias A. Böhme, Susanne Ditlevsen, Jakob Balslev Sørensen, Alexander M. Walter

Rapid Active Zone Remodeling Consolidates Presynaptic Potentiation
Rapid Active Zone Remodeling Consolidates Presynaptic Potentiation

Nature Communications, March 2019

Mathias A. Böhme, Anthony W. McCarthy, Andreas T. Grasskamp, Christine B. Beuschel, Pragya Goel, Meida Jusyte, Desiree Laber, Sheng Huang, Ulises Rey, Astrid G. Petzoldt, Martin Lehmann, Fabian Göttfert, Pejmun Haghighi, Stefan W. Hell, David Owald, Dion Dickman, Stephan J. Sigrist & Alexander M. Walter

Stable Positioning Of Unc13 Restricts Synaptic Vesicle Fusion To Defined Release Sites To Promote Synchronous Neurotransmission
Stable Positioning Of Unc13 Restricts Synaptic Vesicle Fusion To Defined Release Sites To Promote Synchronous Neurotransmission

Neuron, September 2017

Suneel Reddy-Alla, Mathias A. Böhme, Eric Reynolds, Christina Beis, Andreas T. Grasskamp, Malou M. Mampell, Marta Maglione, Meida Jusyte, Ulises Rey, Husam Babikir, Anthony W. McCarthy, Christine Quentin, Tanja Matkovic, Dominique Dufour Bergeron, Zeeshan Mushtaq, Fabian Göttfert, David Owald, Thorsten Mielke, Stefan W. Hell, Stephan J. Sigrist, Alexander M. Walter

Active Zone Scaffolds Differentially Accumulate Unc13 Isoforms To Tune Calcium Channel-Vesicle Coupling
Active Zone Scaffolds Differentially Accumulate Unc13 Isoforms To Tune Calcium Channel-Vesicle Coupling

Nature Neuroscience, August 2016

Mathias A Böhme, Christina Beis, Suneel Reddy-Alla, Eric Reynolds, Malou M Mampell, Andreas T Grasskamp, Janine Lützkendorf, Dominique Dufour Bergeron, Jan H Driller, Husam Babikir, Fabian Göttfert, Iain M Robinson, Cahir J O'Kane, Stefan W Hell, Markus C Wahl, Ulrich Stelzl, Bernhard Loll, Alexander M Walter & Stephan J Sigrist

Preprints

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Busy research flies are working!

More to come soon, but check out our other papers while you're here!

All Publications

Featured
Manon's Paper is Published!
Manon's Paper is Published!

Independently engaging protein tethers of different length enhance synaptic vesicle trafficking to the plasma membrane

Click here to read more!

Using computational modelling, we show that proteins and protein complexes of different lengths, such as synaptotagmin-1, Munc13, and the SNARE complex, as well as their abundance at the active zone can enhance synaptic vesicle trafficking to the plasma membrane

Synaptotagmin 7 docks synaptic vesicles to support facilitation and Doc2α-triggered asynchronous release
Synaptotagmin 7 docks synaptic vesicles to support facilitation and Doc2α-triggered asynchronous release

eLife, March 2024

Zhenyong Wu, Grant F Kusick, Manon MM Berns, Sumana Raychaudhuri, Kie Itoh, Alexander M Walter, Edwin R Chapman, Shigeki Watanabe

Rate-limiting recovery processes in neurotransmission under sustained stimulation
Rate-limiting recovery processes in neurotransmission under sustained stimulation

Mathematical Biosciences, August 2023

Ariane Ernst, Nathalie Unger, Christof Schütte, Alexander M Walter, Stefanie Winkelmann

Unc13A dynamically stabilizes vesicle priming at synaptic release sites for short-term facilitation and homeostatic potentiation
Unc13A dynamically stabilizes vesicle priming at synaptic release sites for short-term facilitation and homeostatic potentiation

Cell reports, June 2023

Meida Jusyte, Natalie Blaum, Mathias A. Bohme, Manon M.M. Berns, Alix E. Bonard, Abel B. Vamosi, Kavya V. Pushpalatha, Janus R.L. Kobbersmed, and Alexander M. Walter

Rate-limiting recovery processes in neurotransmission under sustained stimulation
Rate-limiting recovery processes in neurotransmission under sustained stimulation

Mathematical Biosciences, May 2023

Ariane Ernst, Nathalie Unger, Christof Schütte, Alexander M. Walter, Stefanie Winkelmann

Spontaneous neurotransmission at evocable synapses predicts their responsiveness to action potentials
Spontaneous neurotransmission at evocable synapses predicts their responsiveness to action potentials

Frontiers in cellular neuroscience, March 2023

Andreas T. Grasskamp, Meida Jusyte, Anthony W. McCarthy, Torsten W. B. Götz, Susanne Ditlevsen and Alexander M. Walter

Allosteric stabilization of calcium and phosphoinositide dual binding engages several synaptotagmins in fast exocytosis
Allosteric stabilization of calcium and phosphoinositide dual binding engages several synaptotagmins in fast exocytosis

Elife, Aug. 2022

Janus RL Kobbersmed, Manon MM Berns, Susanne Ditlevsen, Jakob Balslev Sørensen, Alexander M Walter

Glial Synaptobrevin mediates peripheral nerve insulation, neural metabolic supply, and is required for motor function
Glial Synaptobrevin mediates peripheral nerve insulation, neural metabolic supply, and is required for motor function

Glia, sep 2021

Mathias A Böhme, Anthony W McCarthy, Natalie Blaum, Monika Berezeckaja , Kristina Ponimaskine, David Schwefel, Alexander M Walter

Live-cell lipid biochemistry reveals a role of diacylglycerol side-chain composition for cellular lipid dynamics and protein affinities
Live-cell lipid biochemistry reveals a role of diacylglycerol side-chain composition for cellular lipid dynamics and protein affinities

PNAS, March 2020

Milena Schuhmacher, Andreas T. Grasskamp, Pavel Barahtjan, Nicolai Wagner, Benoit Lombardot, Jan S. Schuhmacher, Pia Sala, Annett Lohmann, Ian Henry, Andrej Shevchenko, Ünal Coskun, Alexander M. Walter, and André Nadler

Rapid regulation of vesicle priming explains synaptic facilitation despite heterogeneous vesicle:Ca2+ channel distances
Rapid regulation of vesicle priming explains synaptic facilitation despite heterogeneous vesicle:Ca2+ channel distances

eLife, Feb 2020

Janus R. L. Kobbersmed, Andreas T. Grasskamp, Meida Jusyte, Mathias A. Böhme, Susanne Ditlevsen, Jakob Balslev Sørensen, Alexander M. Walter

Rapid Active Zone Remodeling Consolidates Presynaptic Potentiation
Rapid Active Zone Remodeling Consolidates Presynaptic Potentiation

Nature Communications, March 2019

Mathias A. Böhme, Anthony W. McCarthy, Andreas T. Grasskamp, Christine B. Beuschel, Pragya Goel, Meida Jusyte, Desiree Laber, Sheng Huang, Ulises Rey, Astrid G. Petzoldt, Martin Lehmann, Fabian Göttfert, Pejmun Haghighi, Stefan W. Hell, David Owald, Dion Dickman, Stephan J. Sigrist & Alexander M. Walter

Homeostatic scaling of active zone scaffolds maintains global synaptic strength
Homeostatic scaling of active zone scaffolds maintains global synaptic strength

Journal of Cell Biology, March 2019

Pragya Goel, Dominique Dufour Bergeron, Mathias A. Böhme, Luke Nunnelly, Martin Lehmann, Christopher Buser, Alexander M. Walter, Stephan J. Sigrist, Dion Dickman

Regulation of synaptic release‐site Ca2+ channel coupling as a mechanism to control release probability and short‐term plasticity
Regulation of synaptic release‐site Ca2+ channel coupling as a mechanism to control release probability and short‐term plasticity

FEBS Letters, July 2018

Mathias A Böhme, Andreas T Grasskamp, Alexander M Walter

Active Zone Scaffold Protein Ratios Tune Functional Diversity across Brain Synapses
Active Zone Scaffold Protein Ratios Tune Functional Diversity across Brain Synapses

Cell Reports, May 2018

Andreas Fulterer, Till F.M. Andlauer, Anatoli Ender, Marta Maglione, Katherine Eyring, Jennifer Woitkuhn, Martin Lehmann, Tanja Matkovic-Rachid, Joerg R.P. Geiger, Alexander M. Walter, Katherine I. Nagel and Stephan J. Sigrist

Vesicle release site organization at synaptic active zones
Vesicle release site organization at synaptic active zones

Neuroscience Research, December 2017

Alexander M. Walter, Mathias A. Böhme, Stephan J. Sigrist

Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis
Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis

eLife, October 2017

Alexander M Walter, Rainer Müller, Bassam Tawfik, Keimpe DB Wierda, Paulo S Pinheiro, André Nadler, Anthony W McCarthy, Iwona Ziomkiewicz, Martin Kruse, Gregor Reither, Jens Rettig, Martin Lehmann, Volker Haucke, Bertil Hille, Carsten Schultz, Jakob Balslev Sørensen

Stable Positioning Of Unc13 Restricts Synaptic Vesicle Fusion To Defined Release Sites To Promote Synchronous Neurotransmission
Stable Positioning Of Unc13 Restricts Synaptic Vesicle Fusion To Defined Release Sites To Promote Synchronous Neurotransmission

Neuron, September 2017

Suneel Reddy-Alla, Mathias A. Böhme, Eric Reynolds, Christina Beis, Andreas T. Grasskamp, Malou M. Mampell, Marta Maglione, Meida Jusyte, Ulises Rey, Husam Babikir, Anthony W. McCarthy, Christine Quentin, Tanja Matkovic, Dominique Dufour Bergeron, Zeeshan Mushtaq, Fabian Göttfert, David Owald, Thorsten Mielke, Stefan W. Hell, Stephan J. Sigrist, Alexander M. Walter

RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses
RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses

PNAS, 2016

M. Katharina Grauel, Marta Maglione, Suneel Reddy-Alla, Claudia G. Willmes, Marisa M. Brockmann, Thorsten Trimbuch, Tanja Rosenmund, Maria Pangalos, Gülçin Vardar, Alexander Stumpf, Alexander M. Walter, Benjamin R. Rost, Britta J. Eickholt, Volker Haucke, Dietmar Schmitz, Stephan J. Sigrist, and Christian Rosenmund

Active Zone Scaffolds Differentially Accumulate Unc13 Isoforms To Tune Calcium Channel-Vesicle Coupling
Active Zone Scaffolds Differentially Accumulate Unc13 Isoforms To Tune Calcium Channel-Vesicle Coupling

Nature Neuroscience, August 2016

Mathias A Böhme, Christina Beis, Suneel Reddy-Alla, Eric Reynolds, Malou M Mampell, Andreas T Grasskamp, Janine Lützkendorf, Dominique Dufour Bergeron, Jan H Driller, Husam Babikir, Fabian Göttfert, Iain M Robinson, Cahir J O'Kane, Stefan W Hell, Markus C Wahl, Ulrich Stelzl, Bernhard Loll, Alexander M Walter & Stephan J Sigrist

Identification of a Munc13-sensitive step in chromaffin cell large dense-core vesicle exocytosis
Identification of a Munc13-sensitive step in chromaffin cell large dense-core vesicle exocytosis

eLIFE, 2015

Kwun Nok M Man, Cordelia Imig, Alexander M Walter, Paulo S Pinheiro, David R Stevens, Jens Rettig, Jakob B Sørensen, Benjamin H Cooper, Nils Brose, Sonja M Wojcik

Presynaptic spinophilin tunes neurexin signalling to control active zone architecture and function
Presynaptic spinophilin tunes neurexin signalling to control active zone architecture and function

Nat Commun., 2015

Karzan Muhammad, Suneel Reddy-Alla, Jan H Driller, Dietmar Schreiner, Ulises Rey, Mathias A. Böhme, Christina Hollmann, Niraja Ramesh, Harald Depner, Janine Lützkendorf, Tanja Matkovic, Torsten Götz, Dominique D. Bergeron, Jan Schmoranzer, Fabian Goettfert, Mathew Holt, Markus C. Wahl, Stefan W. Hell, Peter Scheiffele, Alexander M. Walter, Bernhard Loll & Stephan J. Sigrist

Additive effects on the energy barrier for synaptic vesicle fusion cause supralinear effects on the vesicle fusion rate
Additive effects on the energy barrier for synaptic vesicle fusion cause supralinear effects on the vesicle fusion rate

eLIFE, 2015

Sebastiaan Schotten, Marieke Meijer, Alexander Matthias Walter, Vincent Huson, Lauren Mamer, Lawrence Kalogreades, Mirelle ter Veer, Marvin Ruiter, Nils Brose, Christian Rosenmund, Jakob Balslev Sørensen, Matthijs Verhage, Lennart Niels Cornelisse

The SNARE protein vti1a functions in dense-core vesicle biogenesis
The SNARE protein vti1a functions in dense-core vesicle biogenesis

EMBO J., Aug 1, 2014

Alexander M Walter, Julia Kurps, Heidi de Wit, Susanne Schöning, Trine L Toft‐Bertelsen, Juliane Lauks, Iwona Ziomkiewicz, Annita N Weiss, Alexander Schulz, Gabriele Fischer von Mollard, Matthijs Verhage, Jakob B Sørensen

Clathrin/AP-2 Mediate Synaptic Vesicle Reformationfrom Endosome-like Vacuoles but Are Not Essentialfor Membrane Retrieval at Central Synapses
Clathrin/AP-2 Mediate Synaptic Vesicle Reformationfrom Endosome-like Vacuoles but Are Not Essentialfor Membrane Retrieval at Central Synapses

Neuron, Jun 4, 2014

Kononenko N.L., Puchkov D., Classen G.A., Walter A.M., Pechstein A., Sawade L., Kaempf N., Trimbuch T., Lorenz D., Rosenmund C., Maritzen T., Haucke V.

A Presynaptic Role for the Cytomatrix Protein GIT in Synaptic Vesicle Recycling
A Presynaptic Role for the Cytomatrix Protein GIT in Synaptic Vesicle Recycling

Cell Reports, Jun 12, 2014

Podufall J., Tian R., Knoche E., Puchkov D., Walter A.M., Rosa S., Quentin C., Vukoja A., Jung N., Lampe A., Wichmann C., Böhme M., Depner H., Zhang Y.Q., Schmoranzer J., Sigrist S.J., Haucke V.

Neurotransmission: Spontaneous and Evoked Release Filing for Divorce
Neurotransmission: Spontaneous and Evoked Release Filing for Divorce

Current Biology, Mar 3, 2014

Walter, A.M. , Haucke, V., and Sigrist, S.J.

A Sequential Vesicle Pool Model with a Single Release Sensor and a Ca2+-Dependent Priming Catalyst Effectively Explains Ca2+-Dependent Properties of Neurosecretion
A Sequential Vesicle Pool Model with a Single Release Sensor and a Ca2+-Dependent Priming Catalyst Effectively Explains Ca2+-Dependent Properties of Neurosecretion

PLoS Comp Biol, Dec 5, 2013

Walter, A.M. , Pinheiro, P.S., Verhage, M., and Sorensen, J.B.

Doc2b Synchronizes Secretion from Chromaffin Cells by Stimulating Fast and Inhibiting Sustained Release
Doc2b Synchronizes Secretion from Chromaffin Cells by Stimulating Fast and Inhibiting Sustained Release

J Neurosci, Oct 16, 2013

Paulo S. Pinheiro, Heidi de Wit, Alexander M. Walter, Alexander J. Groffen, Matthijs Verhage and Jakob B. Sørensen

Multiple Ca2+ sensors in secretion: teammates, competitors or autocrats?
Multiple Ca2+ sensors in secretion: teammates, competitors or autocrats?

Trends Neurosci., Sep 2011

Walter A.M., Groffen A.J., Sørensen J.B., Verhage M.

Synaptobrevin N-terminally bound to syntaxin–SNAP-25 defines the primed vesicle state in regulated exocytosis
Synaptobrevin N-terminally bound to syntaxin–SNAP-25 defines the primed vesicle state in regulated exocytosis

J Cell Biol, Jan 2010

Walter, A.M. , Wiederhold, K., Bruns, D., Fasshauer, D., and Sorensen, J.B.

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