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Manon's Paper is Published!
Independently engaging protein tethers of different length enhance synaptic vesicle trafficking to the plasma membrane
Using computational modelling, we show that proteins and protein complexes of different lengths, such as synaptotagmin-1, Munc13, and the SNARE complex, as well as their abundance at the active zone can enhance synaptic vesicle trafficking to the plasma membrane
Synaptotagmin 7 docks synaptic vesicles to support facilitation and Doc2α-triggered asynchronous release
Unc13A dynamically stabilizes vesicle priming at synaptic release sites for short-term facilitation and homeostatic potentiation
Spontaneous neurotransmission at evocable synapses predicts their responsiveness to action potentials
Allosteric stabilization of calcium and phosphoinositide dual binding engages several synaptotagmins in fast exocytosis
Elife, aug. 2022
Janus RL Kobbersmed, Manon MM Berns, Susanne Ditlevsen, Jakob Balslev Sørensen, Alexander M Walter
Glial Synaptobrevin mediates peripheral nerve insulation, neural metabolic supply, and is required for motor function
Glia, sep 2021
Mathias A Böhme , Anthony W McCarthy, Natalie Blaum , Monika Berezeckaja , Kristina Ponimaskine , David Schwefel, Alexander M Walter
Rapid regulation of vesicle priming explains synaptic facilitation despite heterogeneous vesicle:Ca2+ channel distances (Copy)
eLife, Feb 2020
Janus R. L. Kobbersmed, Andreas T. Grasskamp, Meida Jusyte, Mathias A. Böhme, Susanne Ditlevsen, Jakob Balslev Sørensen, Alexander M. Walter
Rapid Active Zone Remodeling Consolidates Presynaptic Potentiation
Nature Communications, March 2019
Mathias A. Böhme, Anthony W. McCarthy, Andreas T. Grasskamp, Christine B. Beuschel, Pragya Goel, Meida Jusyte, Desiree Laber, Sheng Huang, Ulises Rey, Astrid G. Petzoldt, Martin Lehmann, Fabian Göttfert, Pejmun Haghighi, Stefan W. Hell, David Owald, Dion Dickman, Stephan J. Sigrist & Alexander M. Walter
Stable Positioning Of Unc13 Restricts Synaptic Vesicle Fusion To Defined Release Sites To Promote Synchronous Neurotransmission
Neuron, September 2017
Suneel Reddy-Alla, Mathias A. Böhme, Eric Reynolds, Christina Beis, Andreas T. Grasskamp, Malou M. Mampell, Marta Maglione, Meida Jusyte, Ulises Rey, Husam Babikir, Anthony W. McCarthy, Christine Quentin, Tanja Matkovic, Dominique Dufour Bergeron, Zeeshan Mushtaq, Fabian Göttfert, David Owald, Thorsten Mielke, Stefan W. Hell, Stephan J. Sigrist, Alexander M. Walter
Active Zone Scaffolds Differentially Accumulate Unc13 Isoforms To Tune Calcium Channel-Vesicle Coupling
Nature Neuroscience, August 2016
Mathias A Böhme, Christina Beis, Suneel Reddy-Alla, Eric Reynolds, Malou M Mampell, Andreas T Grasskamp, Janine Lützkendorf, Dominique Dufour Bergeron, Jan H Driller, Husam Babikir, Fabian Göttfert, Iain M Robinson, Cahir J O'Kane, Stefan W Hell, Markus C Wahl, Ulrich Stelzl, Bernhard Loll, Alexander M Walter & Stephan J Sigrist