Our Vision
The nervous system continuously adapts to changing physiological demands while maintaining remarkably reliable information processing. Understanding the biological principles that enable this adaptive flexibility - and why they fail in ageing and disease - is one of the central challenges in neuroscience.
We believe that answering this question requires quantitative approaches that bridge molecular mechanisms with nervous system function across scales. To uncover these principles, we combine quantitative neurophysiology, computational modelling, advanced optical imaging, and cross-species experimental systems. By integrating molecular, cellular, and organismal approaches across genetically tractable model organisms and patient-derived human neurons, we aim to establish predictive principles of adaptive nervous system function.
Our work suggests that the sites of neurotransmitter release represent a conserved hub for adaptive regulation of nervous system function. Building on these discoveries, we seek to uncover the quantitative principles by which adaptive changes at these sites shape neural computation across biological scales, species, and physiological contexts - from behavioral flexibility and information storage to aging and neurological disease.
Supported by the European Research Council (ERC) and the Novo Nordisk Foundation, we are working towards a predictive understanding of adaptive nervous system function across scales and species, in health and disease.
Lab News
News
Where to find us:
Our lab can be found in the Panum Building of the University of Copenhagen, Faculty of Health and Medical Sciences, Blegdamsvej 3B, 2200 Copenhagen